Side Effects stands out in the crowded tabletop market with its bold theme and fast-paced mechanics. Players start with four randomly dealt Disorder cards—representing conditions like depression, anxiety, or gambling addiction—face-up in their "psyche." The objective is to be the first to cure all disorders using Drug or Therapy cards while strategically inflicting new disorders on opponents through drug side effects. As noted on pillboxgames.com, the game’s 89 beautifully illustrated cards and simple 3-minute learning curve make it accessible yet deeply tactical.
Side Effects’ mental health theme is both its strength and a point of contention. Reviews on board-game.co.uk commend its respectful approach, noting that the humor comes from the “take-that” mechanics, not the disorders themselves. For players with personal experience, the game can foster meaningful conversations in a fun setting. However, tabletopgaming.co.uk critiques its tone as occasionally off, suggesting the theme may not resonate with everyone due to its sensitive subject matter.
Side Effects is a standout card game that blends strategy, humor, and striking visuals into a compact, replayable package. Its “take-that” mechanics, unique mental health theme, and accessible gameplay make it a hit for game nights and casual gatherings. While its theme may not suit everyone, its respectful approach and tactical depth have earned it critical acclaim and a dedicated fanbase.
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